Speaker: Jiang Du, Ph.D.
Professor of Radiology, University of California, San Diego
Time: 15:00-16:00, November 20
Venue：C505, Administration Building.
Abstract: Conventional magnetic resonance imaging (MRI) techniques have been employed to image and quantify tissues or tissue components with relatively long transverse relaxation times (T2s or T2*s). MR relaxation properties, including spin-lattice relaxation time (T1), relaxation time in the rotating frame (T1rho), T2* and T2, as well as tissue properties such as proton density and susceptibility have been measured for tissues evaluation. However, the human body also contains a number of tissues with predominantly short T2 components such as calcified cartilage, subchondral bone, menisci, ligaments, tendons, vascular calcification, myelin lipid in white matter of the brain, cortical and trabecular bone, etc. These tissues or tissue components have T2s ranging from sub-milliseconds to several milliseconds and are largely “invisible” with conventional clinical MR sequences with typical echo times (TEs) of several milliseconds or longer. We have developed Ultrashort Echo Time (UTE) sequences with minimum nominal TEs of 8 µs that is about 100~1000 times shorter than conventional TEs of several milliseconds or longer, and this makes it possible to detect proton signal from short T2 tissues or tissue components. In this talk a series of contrast mechanisms will be introduced for high resolution morphological imaging of short T2 tissues or tissue components in vitro and in vivo. Quantitative imaging techniques to measure MR and tissue properties (such as T1, T2, T2*, T1rho, magnetization transfer ratio, perfusion, diffusion, susceptibility, total/bound/free water, etc) of these tissues or tissue components will be discussed. The applications in osteoporosis, osteoarthritis and multiple sclerosis will also be briefly mentioned.
Bio : Jiang Du, Ph.D., is a Professor of Radiology of the University of California, San Diego (UCSD). Dr. Du received his bachelor degree in nuclear physics from Beijing University in 1995, master degree in solid state physics from Institute of Physics, Chinese Academy of Sciences in 1998, and Ph.D. degree in medical physics from the University of Wisconsin-Madison in 2003. Dr. Du joined the radiology department of UCSD as an Assistant Professor in 2005, and was promoted to Associate Professor in 2010 and Professor in 2016. Dr. Du’s research interests have focused on ultrashort TE (UTE) imaging of short T2 tissues or tissue components such as cortical bone, tendons, menisci, ligaments, calcification, iron, myelin, etc. Dr. Du has developed a series of UTE imaging techniques with 7 US patents awarded. Dr. Du has authored more than 100 peer-reviewed articles with a focus on osteoarthritis, osteoporosis, atherosclerosis, and multiple sclerosis. Dr. Du is on the editorial board of several scientific journals including Editor of BioMed Research International, and is an active reviewer for more than 20 scientific journals. Dr. Du has served on many grant review committees including American Institute of Biological Sciences (AIBS), Skeletal Biology Structure and Regeneration (SBSR), Surgical Sciences, Biomedical Imaging and Bioengineering (SBIR), Department of Defense (DOD), RSNA, Hong Kong Research Grants Council, Netherlands Technology Foundation STW, etc. Du’s research has been well funded by National Institute of Health (NIH) with three active R01s as PI. Dr. Du’s work has stimulated significant interest among major MR equipment vendors. He has established a close collaboration with GE Healthcare with five grants awarded in the past 10 years. Dr. Du has received numerous awards including the Agfa HealthCare/RSNA Research Scholar in 2008, the American Heart Young Investigator Award in 2008, 1st place poster award from ISMRM in 2011, Outstanding Teacher Award from ISMRM in 2012, and Excellence Award from the International Skeletal Society (ISS) in 2014. Dr. Du is the Co-Chair of 2017 ISMRM Workshop on “Advanced Musculoskeletal MRI: Arthritis & Beyond”, and President-Elect of Overseas Chinese Society for Magnetic Resonance in Medicine (OCSMRM).
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